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Bioavailability of IGF-1 is affected by insulin-like growth factor binding proteins (IGFBPs) which bind IGF-1 in circulation with an affinity equal to or greater than that of the IGF-1 receptor (IGF-1R)

Memory and cognitive decline primarily stem from the impairment of brain regions responsible for learning and synaptic transmission

Tissues were homogenized using a Tenbroeck homogenizer in 50 mM K-phosphate buffer, pH 7.4, containing 0.25 M sucrose, 1 mM K-EDTA, and 0.1 mM dithiothreitol

Zuckerman JE, Davis ME

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McGurnaghan SJ, Weir A, Bishop J, Kennedy S, Blackbourn LAK, McAllister DA, et al