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A lack of enzymatic decomposition of extracellular glutamate results in glutamate accumulating at synapses, which is mainly absorbed by excitatory amino acid transporters (EAATs)

Q.KongL.LuoJ.et al

Halogen facilitates the binding with the enzyme because it increases the binding affinity and binding selectivity, and adding halogens to lead during drug development is well recognized to be a general optimizing approach [31]

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Acta Biol Szeged 49: 19-22, 2005

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