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To provide novel concepts and strategies for overcoming AML treatment resistance and improving patient outcomes, the present review examines the RCD modes of action, their key functions, and potential synergistic effects in maintaining LSCs, chemoresistance and bone marrow microenvironment remodeling

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This finding has important safety implications, as elevated IGF-1 levels associated with full GH therapy raise concerns about increased cancer risk, particularly for individuals with pre-existing malignancies or strong family histories

doi:10.1093/eurheartj/ehaa736

Since elevated Akt activity in the early postprandial stage is required to reduce HGP and Akt activity in the late stage is sufficient to increase de novo lipogenesis but not HGP [40,43,44], unterminated prolonged Akt activity might enhance de novo lipogenesis but not suppress HGP

J Chromatogr B Anal Technol Biomed Life Sci 776:89100