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As the only enzyme shared between the TCA cycle and the ETC, complex II functions as a key metabolic node that directly feeds carbon and reducing equivalents into mitochondrial respiration and CoQ 10 redox cycling 75,76

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Nazroglu et al

Pathway analysis on gene sets and ordered vector of genes (Gene Set Enrichment Analysis) was performed with clusterProfiler 93 (v4.6.2) and fgsea 94 (1.24.0) R packages using Gene Ontology (GO) biological process (2022-07-01) and Kyoto Encyclopedia of Genes and Genomes (KEGG, 2023) pathway datasets

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