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Vitamin B12 Deficiency Among People Taking PPIs: A study in the Journal of the American Medical Association revealed that people who took such acid-suppressing drugs for at least two years were two-thirds more likely to have a vitamin B12 deficiency compared to people not taking powerful acid suppressors

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Although leg cramps are not listed as an official adverse effect in FDA prescribing information, understanding the potential indirect mechanismsincluding dehydration, electrolyte imbalances, and nutritional changescan help patients and clinicians address this symptom effectively while continuing therapy

Y.et al (2016)