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However, tumor-associated blood vessels are dysfunctional and leaky (93), and the continuous exposure of BECs to pro-angiogenic factors can lead to endothelial anergy, a state in which ECs stop responding to inflammatory signals (90)

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The following sections will elaborate on the effect of GM and its metabolites on atherosclerosis, MI, HF, hypertension, and related mechanisms (Figure 2)

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doi: 10.1016/S0167-4889(99)00095-6 45 KanamoriHKriegSMaoCDi PippoVAWangSZajchowskiDAet al