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Components of this complex prefrontalACCpallido-striatalthalamicamygdala network have altered function and structure in individuals suffering from bipolar disorder when compared with healthy populations (Figure 2)

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This effect is likely to be mediated through several pathways: a) Upregulation of antioxidant enzymes: The significant increase in catalase levels observed in the IF group suggests that IF enhances endogenous antioxidant defenses, as catalase is a key enzyme in detoxifying hydrogen peroxide and mitigating oxidative stress