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Nevertheless, attempts to develop melatonin as a contraceptive pill in combination with progestin have not been successful (58)

Consistent with the notion that GSH per se does not regulate mTORC1 and the ISR, depletion of intracellular GSH exacerbated the loss of mTORC1 signaling upon cystine deprivation, but was without observable effect in the presence of cystine (Fig