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In contrast, M2 macrophages are promoted by interleukin-4 (IL-4), interleukin 13(IL-13), and immune complexes (ICs) and are associated with anti-inflammatory functions, including the resolution of inflammation and tissue repair 8

This observation indicates that, at a certain level, GSH application can partly reverse the mutant phenotype

The release and excessive accumulation of collagen fibers caused by overactivated fibroblasts, which are marked with fibroblast activation protein (FAP), lead to pathological changes in the extracellular matrix (ECM) and persistent inflammation, resulting in a vicious cycle of cellular activity and extracellular fibrosis 3,4,5,6,7

Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA)

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Mohtashami, Z., Singh, M