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The QCN-HS also exhibited histological evidence of dermal repair, including reduced inflammatory infiltration, organized collagen deposition, and enhanced vascular density, supporting the observed molecular changes

Given that the degradation of KEAP1 encompasses two distinct pathways, namely autophagy 29 and proteasomal degradation 30 , we employed the protein synthesis inhibitor cycloheximide (CHX), the proteasome inhibitor MG132, and the autophagy inhibitor chloroquine (Chlq) to further explore the underlying mechanism in macrophages (Fig