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Although flushing from nicotinamide is rare, the Food and Nutrition Board set the tolerable upper intake level (UL) for niacin (nicotinic acid and nicotinamide) at 35 mg/day in adults to avoid the adverse effect of flushing (41

Any physician or clinic prescribing these substances outside of a formal, FDA-sanctioned clinical trial is operating outside the standard of care

It devoids any harm or systemic toxicity to essential organs

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While the research was conducted at Seoul National University with IRB approval, commercial funding is a standard disclosure to note