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Figure 2B)

For instance, in AD mice, mitochondrial damage increases mtDNA leakage into the cytosol, where it engages cGAS and activates STING, driving microglial secretion of type I interferons and pro-inflammatory cytokines that contribute to neuronal dysfunction [93]

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Conclusions In summary, this study indicates the potential role of stem cell therapy in modulating mitochondrial function and highlights the role of activation the DDIT4/PGC-1 pathway in protecting hepatic mitochondria to alleviate AILI