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doi: 10.1016/j.ccr.2024.216062

Other studies revealed that exposing human umbilical vein endothelial cells (HUVECs) to arecoline increases the expression of bFGF and ET-1 while down-regulating interleukin (IL)-1, IL-6, G-CSF, and GM-CSF, and these abnormally secreted cytokines by endothelial cells further regulate the proliferation of fibroblasts and promote the occurrence and development of OSF

T.IslamK.et al

However, if the needle goes too far, is not inserted cleanly (for instance, if the nurse fishes for a vein once the needle is under the skin), or moves during insertion, the punctured vein can begin to leak blood into the surrounding tissue

Smoday I.M., Petrovic I., Kalogjera L., Vranes H., Zizek H., Krezic I., Gojkovic S., Skorak I., Hriberski K., Brizic I., et al