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Broekaart DW, van Scheppingen J, Geijtenbeek KW, Zuidberg MR, Anink JJ, Baayen JC, et al

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles heel conserved region to minimize probability of escape mutations and drug resistance

Elevated accumulation of AGEs can enhance gut barrier dysfunction, intestinal permeability, and bacterial translocation by stimulating the production and release of proinflammatory cytokines, potentially toxic metabolites and bacterial products, as well as causing intestinal epithelial cell damage, contributing to systemic endotoxemia, inflammation, and multiorgan injury 98

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The inhibition of these enzymes abolished the antioxidant effect, thereby confirming the enzymatic nature of the pathway