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These large-scale studies randomize hundreds to thousands of patients with the target disease to receive either the experimental drug, placebo, or current gold-standard treatment to definitively prove comparative efficacy

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Upon careful estimation, we determined that assigning 135 patients to both the study and control groups would yield more than 80% power to detect between-group differences

Pinch the area of skin and use the right injection techniques to administer HCG

(PDF 253 kb) Additional file 5: Table S2

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