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4.1.1 Increased glycolysis in hypoxia, pro-inflammatory conditions and monocyte/macrophage trained immunity In hypoxic conditions - such as in atherosclerotic lesions with a high content of proliferating and metabolically active cells -, glycolysis is upregulated through increased hypoxia-inducing factor (HIF)1 mediated expression of glycolysis-regulating genes, such as PFKFB3 (Folco et al., 2011

Following this, the likely role of APP and A isoforms are as copper scavengers, since they both contain copper binding domains with high affinity for copper ions (Kong et al., 2008

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Daily intraperitoneal injection of VGB4 at different doses (0.25, 1, 2.5, 5 and 10 mg/kg) or scr (10 mg/kg) was administrated for treated groups whereas the control group received the equal volume of PBS for two weeks