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The approval marks the fourth NSCLC indication for Tagrisso, which is also authorized for the first-line treatment of metastatic disease, as an adjuvant therapy after resection and in metastatic NSCLC that has progressed after EGFR tyrosine kinase inhibitor (TKI) treatment

We suggest that translational arterial stiffness research should (i) improve clinical assessment, (ii) identify specific pheno- and endotypes, (iii) decipher underlying mechanisms and new risk factors (e.g., chronic psychosocial stress, air pollution), and (iv) develop tailored prevention and therapy approaches (Fig

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