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Notably, specific strains, such as Bifidobacterium pseudolongum, excessively proliferate and disrupt the barrier in Allergin-1-deficient mice, while neomycin can reverse this effect, indicating that immune receptors influence barrier function by modulating the microbiota composition [111]

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Sirtuin-1 is the main deacetylase of PGC-1 ( PGC-1 could dock on NRF 1 and 2 to together drive the transcription and translation of the genes involving TCA cycle and OXPHOS systems, and then induce mitochondrial biogenesis

Sasaki M, Tanaka M, Kojima Y, Nishie H, Shimura T, Kubota E, et al

Wang Y, Picard M, Gu Z

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