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373 Pathway inhibitors: targeting CSC-specific signaling pathways CSCs rely on key developmental signaling pathways, including the Notch, Hedgehog, Wnt, and PI3K/AKT/mTOR pathways, to sustain their self-renewal, survival, and differentiation capacity

Until recently, the only way to assimilate a concentrated dose of glutathione was through intravenous administration: expensive, time-consuming and impractical

Glutathione protects collagen in the body, collagen is too important in protecting the skin from aging

While these therapies have shown significant success, they come with certain limitations, mainly associated with the development of resistance and side effects

Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo

Abbreviations 3HSD: 3-Hydroxysteroid dehydrogenase AI: Aromatase inhibitors BC: Breast cancer CDK2: Cyclin-dependent kinase 2 DALYs: Disability-adjusted life year EGCG: Epigallocatechin gallate ER: Estrogen receptors HaCaT: Cultured human keratinocyte HepG2: Hepatoma G2 HER2: Human epidermal growth factor receptor 2 MCF-7: Michigan cancer foundation-7 MDO: Modularly designed organocatalysts MTT: (3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) NSCLC: Non-small cell lung cancer PR: Progesterone receptor SAR: Structure activity relationship SERMs: Selective estrogen receptor modulators References World Health Organization