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Each protomer contains a canonical fold of enoyl-ACP reductase, wherein several -helices and -strands of the central Rossmann fold form a deep crevice [70]

Vascular perfusion and hypoxia To study the functional impact of tumor vasculatures in response to various monotherapy and combination therapy, we measured blood perfusion and vascular permeability using lysinated Rhodamine-labeled 2000 kDa and 70 kDa dextrans 31,32

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Finally, a flow cytometer (CytoFLEX, Beckman Coulter) was used to measure the apoptosis of cells