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People with depression often have too much of the chemical glutamate in their systems, and if it goes unchecked, it can damage neurons and reduce your response to depression treatment

10.1007/s00018-018-2852-6 139 ZhaoX.LiZ.WangG.ZhangS.LiK

Nonetheless, prolonged endurance exercise performed at moderate-to-high intensities often results in oxidative damage to skeletal muscles of untrained individuals

[41] [42] Functional vitamin B 12 deficiency can also develop with heavy regular use of nitrous oxide N 2 O, also known as "laughing gas", by oxidizing the cobalt atom and inactivating the vitamin

And believe it or not, your subjective interpretation of what's happening has a profound influence on your experience of pleasure or pain

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