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Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

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Schmitt C, Hofmann C, Riek M, Patel A, Zwanziger E

In vivo L2-Cmu validation studies were performed in 45-mo-old C57BL/6J male mice (Jackson Labs, Bar Harbor, ME)

Possible reasons may include the difficulty in distinguishing the effects of endogenous versus exogenous lactate, as well as challenges in translating findings into broad clinical applications