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Lipoxygenase Lipoxygenases (LOs) are a family of enzymes that catalyze the addition of oxygen to polyunsaturated fatty acids (PUFAs), specifically those containing a 1,4-pentadiene structure [245]

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I In a mouse model with a knockout of the Dnmt3b gene, the absence of DNMT3B accelerates the development of lymphoma, indicating that DNMT3B may act as a tumor suppressor gene in normal cells, inhibiting tumor development by stabilizing DNA methylation patterns

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Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas