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The crystal structures of PtGSTU20 complexed with these molecules provide evidence for their potential involvement in flavonoid transport in P

10.1038/s41392-023-01381-z 138 YaoC.GuanX.CarraroG.ParimonT.LiuX.HuangG.et al (2021)

2.3 Key bile acid-sensing receptors modulating the TIME 2.3.1 Farnesoid X receptor: transcriptional control linking metabolism and immunity in the TIME The farnesoid X receptor (FXR, encoded by NR1H4), a nuclear receptor superfamily member, is highly expressed in enterohepatic tissues and various immune cells (e.g., macrophages, DCs, T cells) ( Functionally, FXR-mediated transcription often promotes anti-inflammatory effects and supports immune homeostasis