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By preferentially promoting cAMP-mediated intracellular pathways, thought to be central to insulin secretion and appetite regulation, this receptor bias may enhance metabolic efficacy while potentially reducing the activation of alternative signalling cascades associated with receptor desensitisation or adverse effects (although the clinical relevance of this remains to be fully established)

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Marquet F, Tung YS, Teichert T, Ferrera VP, Konofagou EE

High expression of HGF was observed in HNSCC patients as compared to the healthy individuals