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Results: A total of 370 participants were evaluated, with a predominance of women (60.8%) and elderly individuals (58.1%)

The maintenance of this cell layer renewal requires tight regulation to avoid any imbalance in homeostasis 14,15

The overall molecular properties of orforglipron, molecular weight approximately 529 Da, moderate lipophilicity (cLogP approximately 3.5), and limited hydrogen bond donors and acceptors, place it within the "drug-like" chemical space defined by Lipinski's Rule of Five, although at the upper boundary

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This is primarily due to the avoidance of thermal damage caused by nanosecond laser stimulation, which can lead to cell death

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