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Description

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In heart failure mouse models, lipid peroxidation products like 4-HNE and acrolein significantly increase, while pathways for detoxifying these toxic aldehydes decrease, leading to further accumulation and exacerbation of muscle atrophy (61)

Neuropathologically, PD is defined by the gradual and selective destruction of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in a significant drop in striatal dopamine levels [5]

Descriptive characteristics of NP and RP groups are shown in Tables 1 and 2

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