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A role of TollIL-1 receptor domain-containing adaptor-inducing IFN- in the host response to Pseudomonas aeruginosa lung infection in mice

177 SeephonkaiP.IsakaM.KittakoopP.TrakulnaleamsaiS.RattanajakR.TanticharoenM.et al (2001)

Above all, chronic inflammation leads to the occurrence and development of PCOS through multiple pathways such as affecting ovarian function, androgen synthesis, and insulin resistance

Further this demonstrates why PrfA* alleles did not rescue virulence of these strains and indicates that the primary defect of these mutants is metabolic in nature