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The number of migrated cells remarkably decreased when ERK1/2 signal pathways were blocked by its inhibitor PD98059 (Figure 7BC)

When these two pathways are activated simultaneously, the effect is multiplicative: GHRH increases the amount of GH released per cell, and GHRP increases the number of responding cells

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However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)

Alone this line, a futuristic multigene transfer can be developed to aim multiple targets and pathways to achieve better therapeutic effect