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Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

doi: 10.1016/j.jhazmat.2020.122969 158 DuF.WangJ.WangT.ZhaoX.LiX.GuoS.et al

Research shows this mechanism gives insights into fat metabolism, muscle health and NAD+ biology

Application of PrediXcan to a large-scale biobank has been shown to enable discovery of gene-level effects on the medical phenome 53

10.1186/s12958-020-00617-9 5 BagavantH.AdamsS.TerranovaP.ChangA.KraemerF