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FIGURE 3 Supplementation with PA alleviated these pathological changes in the form of clear central veins and sinusoids

The peptide modulates beta-3 adrenergic receptors on fat cell membranes, activating G-proteins that stimulate adenylyl cyclase enzyme

Patients in the dose reduction group were switched to either reduced dose (37.5mg daily, n = 20) or alternate-day dosing (75mg every other day, n = 34) based on clinical assessment