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The details of the chemistry behind the reaction are available from vendor product literature, but briefly, the assay utilizes two bead types, a glutathione-coated acceptor bead which binds recombinant human FcR-Glutathione-s-transferase (FcR-GST), and a streptavidin donor bead which contains a photosensitizer and binds to biotinylated human IgG1

However, excessive chelation of copper by these compounds can lead to cellular copper deficiency and cell death (9) (Fig