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As damage from smoking or even pollution accumulates to the respiratory tract and the lungs, oxygen and carbon dioxide (CO2) exchange suffers, making it difficult to breathe

For example, -asarone has demonstrated efficacy in mitigating ERS by modulating the expression of ERS-related proteins such as GRP78, p-PERK, and CHOP

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Allyl-substituted polysulfides undergo nucleophilic substitution at the allyl substituent's -carbon to form hydropolysulfide (RSnH), a key intermediate in H 2 S synthesis

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

10.1016/j.prrv.2016.10.005 149 PettitR