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Statements Author contributions AH and KA: concept

Gaggini et al

Regulatory bodies such as the FDA and EMA have implemented rigorous guidelines to address the specific challenges encountered with pulmonary nanotherapeutics, ensuring comprehensive preclinical evaluations including pharmacokinetics, biodistribution, and toxicity studies, with particular attention to lung-specific endpoints like alveolar inflammation and mucociliary clearance ( 2+ release (Sun et al., 2023)

Acetyl L-Carnitine is commonly used to support energy metabolism and help the body use stored energy more efficiently

However, 1 O 2 has a brief lifespan and limited diffusion range, restricting its damage within the cell diameter

Front Immunol (2022) 13:916664