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Akinfemiwa, O., Zubair, M., & Muniraj, T

Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection (Cardona-Gmez et al., 2006)

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The study utilizing single-voxel proton magnetic resonance spectroscopy (1H MRS) to analyze glutamate levels relative to creatine in individuals with Primary Insomnia (PI) suggests no significant direct association between glutamate concentrations in the dorsal anterior cingulate cortex (dACC) and measures of sleep quality within subjects with Major Depressive Disorder (MDD)

You can read the full Lumo specifications on its product page