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5d) and increased fluorescence of the acs-2 p::GFP reporter by 68% (Supplementary Fig

Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

The Wilks' Lambda and squared Mahalanobis distances statistics were used to evaluate the significance in group separation (44,46)

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Wang Y., Xia R., Hu H., Peng T

Bridging the gap: the role of advanced formulation strategies in the clinical translation of nanoparticle-based drug delivery systems