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(Menopause definitely counts as a time of stress!) Epidemiological studies have shown higher vitamin C plasma concentrations in women, suggesting that women may need more of it than men , and low concentrations in both sexes have been associated with symptoms of aging, including cognitive decline

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Vandeputte et al., 2016)

13 C-NMR (100 MHz, CDCl 3 ) ppm = 171.1, 164.4, 150.5, 142.8, 134.9, 134.4, 132.9, 129.0, 128.9, 128.4, 128.0, 127.9, 127.0,0 124.0, 123.9, 123.4, 119.9, 109.3, 50.9, 46.5, 21.9, 20.7, 11.4, 11.1

High-dose administration of either pro-inflammatory agents [e.g., Lipopolysaccharide (LPS)] or anti-inflammatory drugs (e.g., ibuprofen) impairs neuroplasticity, whereas low-dose treatments produce minimal adverse effects (Golia et al., 2019)

Streba LA, Vere CC, Ionescu AG, Streba CT, Rogoveanu I