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Porporato PE

Ariadne RBR E3 ubiquitin protein ligase 2 is a pivotal downstream mediator in this process and is involved in aging-associated muscle degeneration and ubiquitin-dependent modification in skeletal muscle

Antonopoulos, D

J.KontoghiorgheC

PBS: Phosphate Buffered Saline

Once activated, TGF- binds to its receptor complex, initiating phosphorylation of Smad2 and Smad3, which then form a complex with Smad4 and translocate to the nucleus and regulate gene transcription (70)