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The therapeutic potential of menadione extends beyond oncology, as demonstrated in a model of an X-linked myotubular myopathy caused by the absence of MTM1, the phosphatase that antagonizes PIK3C3

Antibodies against KDM4A (A300-861A), KDM4C (A300-885A), and KDM5B (A301-813A) were obtained from Thermo Fisher Scientific

Here, most effects were found in pathways citric acid cycle and respiratory electron transport (q-value: 3.5 * 10 10 , 63 DEGs out of 171 genes, 76.2% downregulated), glucose metabolism (q-value: 9.9 * 10 9 , 36 DEGs out of 77 genes, 80.5% downregulated) and metabolism of lipids and lipoproteins (q-value: 2.9 * 10 6 , 165 DEGs out of 728 genes, 55.2% downregulated)

A.Herrera-MundoN.Victoria-AcostaG.Corts-MalagnE

Morgan S, Anderson RA, Gourley C, Wallace WH, Spears N (2012) How do chemotherapeutic agents damage the ovary

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