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The American journal of medicine, 93(1A), 8S12S

Cotinine is further metabolised to the molecule trans 3-hydroxycotinine (3-HCOT), a reaction that is also mediated by CYP2A6

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[244] Some long-term effects of nicotine may be irreversible because "it is entirely possible that doses of nicotine achieved in the brains of human smokers can damage or kill mHb [medial habenula] neurons that regulate nicotine avoidance behaviors", but more studies are needed to elucidate this underlying mechanism of nicotine-induced degeneration of the mHb-IPn circuit

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26 carried out a study that aimed at estimating the impact of tobacco taxes on different socioeconomic groups