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Thats why B12 injections are often given as treatment

The sgRNA sequences are available in Supplementary Data 2

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J Biol Chem (2001) 276:3200815.10.1074/jbc.M104794200 36 KobayashiEHSuzukiTFunayamaRNagashimaTHayashiMSekineHet alNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription