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These cryogenic injuries are mainly attributed to osmotic stress, cold shock, intracellular ice formation, and the excessive generation of reactive oxygen species (ROS) during the freezing and thawing process 3

Because the concept of CHE was initiated by ISHEN in 2011, most previous studies have been done on MHE

Urolithin A protects dopaminergic neurons in experimental models of Parkinsons disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1 signaling pathway

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