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The figure also shows the net reaction: -ketoacid + CoASH (coenzyme A) + NAD + acyl-CoA + CO 2 + NADH + H +

Regulation of redox states of plasma proteins by metabolism and transport of glutathione and related compounds[J]

Plasminogen activator inhibitor type-1 (PAI-1) has major fibrosis effects in the kidney

The precise mechanisms underlying this process are as follows: activation of the transforming growth factor-beta signaling pathway induces the phosphorylation of Smad2/3, subsequently enhancing the production of type I collagen