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V(D)J recombination and clonal selection followed by an iterative affinity maturation process results in a broad and flexible B-cell receptor repertoire, eventually giving rise to plasma cells (PCs) that produce the corresponding antibody response [43]

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doi:10.1016/j.pdpdt.2020.102070 Dougal G, Lee SY

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Furthermore, t-distributed Stochastic Neighbor Embedding (t-SNE) clustering under disease conditions ( Figure 6B ) reveals pathological remodeling of renal cellular subpopulations in acute kidney disease (AKD) and CKD, establishing a foundation for exploring the cell-selective roles of ferroptosis during renal injury progression