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Future development of iron-targeting therapeutics should prioritize agents with verified bloodbrain barrier permeability, minimal systemic toxicity, and the capacity to restore both iron homeostasis and redox balance

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This EPO-R/CD131 selectivity allows for neuroprotection and tissue repair without the thrombotic risks of erythropoietin

METTL16 underwent site-specific S-glutathionylation at Cys548, leading to its degradation and subsequent m 6 A loss

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He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW