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The peptide is also being studied for its potential to promote cartilage repair and connective tissue regeneration

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declining NAD+ levels are associated with senescence-associated secretory phenotype (SASP) in ageing research models Neurodegeneration models reduced NAD+ is associated with impaired neuronal energy metabolism and increased susceptibility to excitotoxicity

The rationale for this warning is that trouble swallowing may indicate a more severe underlying disease state than just heartburn alone