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doi: 10.1172/JCI119176 45

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Acknowledgements We thank Marian Bulthuis for the technical support with slide scanning

The biochemical characteristics of ferroptosis are mainly manifested as the accumulation of intracellular iron, the production of reactive oxygen species (ROS), the increase of lipid peroxides, and the decreased expression of glutathione peroxidase 4 in antioxidant system (glutathione system) [21]