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ACSL4 is able to induce ferroptosis, and increasing its expression would exacerbate inflammation, OS and cognitive deficits after SAH (Qu et al., 2021)

The IGF-1 stimulation, glucose effects, and growth-promoting properties come from a different region of HGH

Beyond enzyme regulation, GHK-Cu acts as a potent epigenetic modulator, influencing the expression of a large fraction of human genes upregulating pathways involved in antioxidant defense, DNA repair, and tissue remodeling while downregulating inflammatory and pro-fibrotic signaling

A1 astrocytes are distinguished by hypertrophy, reduced expression of essential ion channels and neurotransmitter receptors, and upregulated glial fibrillary acidic protein (GFAP) expression, ultimately disrupting the BBB (44)

Acta Pharm Sin B 13:498516 Gaspar D, Freire JM, Pacheco TR, Barata JT, Castanho MA (2015) Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

These results suggested that -syn played a critical role in neuronal injury induced by chronic hypoxia