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L-citrulline has been less extensively studied but preliminary evidence suggests it may be more effective than L-arginine due to better bioavailability

Cryobiology (2017) 74:2530

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Additionally, modeling of PK/PD and efficacy data from human tumor cell xenografts in mice led to the determination of 125 g/mg protein as the target level of PD biomarker Met-EF1 associated with M8891 efficacy, which was pivotal in the definition of the recommended phase II dose