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A critical unanswered question is whether this immune dysregulation is a carryover from an initial infection, or whether it reflects ongoing chronic immune activation infection or inflammation when the initial infection has resolved

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Ethics declarations Acknowledgements This work was undertaken as part of UK Biobank project application ref 56653 Pharmacogenomics to improve drug efficacy and safety

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Without those findings, the elevation is better weighed against the broader metabolic picture and any comorbidities